Khan made her acting debut in 2003, as Guddi, in the TV Series Lipstick.

She has worked under well-known banners of the Mumbai Film Industry[3] and with several producers and directors, for several television serials and movies (Ref the following section "Filmography").

In addition to her on-screen contribution, Gulfam Khan started writing screenplays in 2007.

Gulfam has also written Comedy Circus Season-1 for Sony Entertainment Television (India).

[5] After playing brothel owner Rasili Bai in Ghar Ki Lakshmi... Betiyann, a madame in the movie Talaash and a slum queen — a boss of all bad deeds — in Mann Mein Hai Vishwas, she has turned down two films and one soap, Bani — Ishq Da Kalma, which required her to repeat the role.