The Gumelniţa–Kodžadermen-Karanovo VI complex was a Chalcolithic cultural complex of the fifth millennium BC located in the eastern Balkans, comprising the Gumelnița, Kodžadermen and Karanovo cultures.

It formed part of the broader cultural complex known as Old Europe.

Gumelniţa–Kodžadermen-Karanovo VI evolved out of the earlier Boian culture and phase V of the Karanovo culture.

From c. 4000 BC Gumelniţa–Kodžadermen-Karanovo VI was replaced by the Cernavodă culture.

During the Middle Copper Age, the Danube script appears in three horizons: The Gumelniţa–Kodžadermen-Karanovo VI cultural complex (mainly in Bulgaria, but also in Romania), the Cucuteni A3-A4–Trypillya B (in Ukraine), and Coțofeni I (in Serbia).