Partnering Ye Qiuyu, Guo made her WTA Tour main-draw debut at the 2017 Tianjin Open, after defeating Dalila Jakupović and Nina Stojanović in qualifying.

[citation needed] Following a fourth final at the Thailand Open in Hia Hin, partnering with Jiang Xinyu,[4] and a first third-round showing on her debut at a major, at the Australian Open, she reached the top 50 in the rankings on 5 February 2024, and a new career-high on 4 March 2024, at No.

[citation needed] In August, Guo won the Monterrey Open doubles title with Monica Niculescu, after beating Giuliana Olmos and Alexandra Panova in the match tiebreaker.

[5] Partnering Moyuka Uchijima, she won her third WTA Tour doubles title at the 2024 Jiangxi Open, defeating Katarzyna Piter and Fanny Stollár in the final.

[6] Partnering with Alexandra Panova, Guo won the doubles title at the Adelaide International, defeating Beatriz Haddad Maia and Laura Siegemund in the final in straight sets.