Ghuggi began his career by acting in theatre in the early 1990s, after which he had recurring roles in television series such as Ronak Mela and the soap opera Parchhaven.

He gained international public recognition with comedic leading roles through his videos Ghuggi Junction (2003) and Ghuggi Shoo Mantar (2004), before beginning his film career by starring as Patwari Jhilmil Singh in Asa Nu Maan Watna Da (2004).

Soon after, he became a cast member in several films, including a breakthrough in 2015, when he was given the opportunity to play the lead role in Ardaas.

He received public recognition in India through his participation in The Great Indian Laughter Challenge, a reality show on STAR One.

In 2020, Ghuggi started a new talk show called Hasdeyaan De Ghar Vasde on Zee Punjabi and Zee5.