Gurupá or Santo Antonio de Gurupá is a municipality on the Amazon River in state of Pará, northern Brazil located near the world's largest river island, Marajó, 300 km upstream from the upper mouth of the river on the Atlantic coast.

Gurupá is derived from the tupi language words guru (mouth) and pa (wide), and is associated with regions where water channels become wider.

[3] Gurupá was founded in 1609 as a Dutch trading post that they called Mariocai, after the indigenous peoples living there.

It was the third of three trading posts established by the Dutch along the lower reaches of the Amazon and Xingu Rivers.

It became the royal captaincy of Gurupá in 1633 in recognition of its strategic military and trading position.