[1] Madero also was the President of the National Action Party (PAN) from 2010 to 2013 and again from 2014 to 2015,[2] and from 2015 to 2018, he was a federal deputy from the first electoral region representing the state of Chihuahua.

[2] He has pursued business interests for most of his life; from 1993 to 1994, he was the Vice President of the COPARMEX in Chihuahua, and he has consulted for hotels and worked for companies including Banamex and ING.

[2] In 1996, Madero joined the PAN,[2] and the next year he served as the Director General of Planning and Evaluation in Chihuahua under Governor Francisco Barrio.

[2] In 2003, voters in the Sixth Federal Electoral District of Chihuahua sent Madero to the Chamber of Deputies for the first time, in the LIX Legislature, after narrowly beating his opponent, Pedro Domínguez Alarcón of the PRI, by 48,683 votes to 48,229.

[3] He presided over the Finances and Public Credit Commission, where he worked hard to have value-added tax applied to medicines and foodstuffs, an (unsuccessful) policy initiative of the Fox administration.