Güstrow (German: [ˈɡʏstʁoː] ⓘ; Latin: Gustrovium) is a town in Mecklenburg-Vorpommern in north-eastern Germany.

There are five lakes (Inselsee, Sumpfsee, Parumer See, Grundloser See and Gliner See) and several forests around Güstrow.

Güstrow is said to be founded by Heinrich Borwin II, a grandson of Henry the Lion, between 1219 and 1226 and was first mentioned in 1228 in the deed of city rights of Schwerin, confirmed by the sons of Heinrich Borwin II, who donated the cathedral as collegiate church in 1226.

The Kapelle des heiligen Bluts (Chapel of the Holy Blood) was built on the site of the synagogue.

(Albrecht von Wallenstein, the imperial general in the Thirty Years' War, was a duke of Mecklenburg-Güstrow.)