Guy's Cliffe (variously spelled with and without an apostrophe and a final "e") is a hamlet and former civil parish on the River Avon and the Coventry Road between Warwick and Leek Wootton, in the parish of Leek Wootton and Guy's Cliffe, in the Warwick district, in Warwickshire, England, near Old Milverton.

The current, ruined house dates from 1751 and was started by Samuel Greatheed, a West India slave-owner, merchant and Member of Parliament for Coventry 1747-1761.

His son Bertie Greatheed inherited the estate after the death of his mother in 1774 and further improved the house and grounds in 1810 to heighten the picturesque qualities of the site.

In 1955 the house was purchased by Aldwyn Porter and the chapel leased to the Freemasons, establishing a connection with the Masons that remains today.

In 1982, during the filming of The Adventures of Sherlock Holmes (The Last Vampyre), a fire scene got out of control and seriously damaged the building, leading to an insurance claim.

The new boundary split the original estate: the stables and nursery are not within the current Parish of Leek Wootton & Guy's Cliffe, but the house, mill and modern homes are.