His HDR Committee included Professors Joëlle Coutaz, Pierre Falzon, Jean-Gabriel Ganascia, Georges Duvaut, Brian R. Gaines, Yves Kodratoff, and Marc Pelegrin.

His work mainly focuses on cognition, aerospace systems, and organizations since the late seventies sharing his time between academia and industry.

In the late eighties, he created and headed the Advanced Interaction Media Group at NASA Ames Research Center, California.

In 2004, Guy André Boy co-founded with Bernard Claverie the French Cognitive Engineering School and Center of Excellence ENSC: École Nationale Supérieure de Cognitique in Bordeaux, France.

After two years in France (1987–1988), where he co-founded a start-up company on intelligent assistant systems, Dialogics/Dialexis, he returned to NASA Ames to work on electronic documentation for the Space Station Freedom (1989–1991).

During this period, influenced by Douglas Englebart, who he worked with for a while, he developed an approach mixing hypertext and machine learning, leading to a system called Computer Integrated Documentation.

He wrote an introductory text under the auspices of UNESCO on theories of human cognition to better understand the co-adaptation of people and technology in knowledge management, organizational intelligence and learning, and complexity.

He then contributed to developing the field of HCI in France and was Co-Founder of AFIHM,[13] the French national equivalent of Association for Computing Machinery SIGCHI.

Within the human-computer interaction community, he collaborated with colleagues who were influential throughout his professional life, including Jeff Bradshaw, John Carroll, Jonathan Grudin, Don Norman, Terry Winograd, among many others.

He also founded the HCI-Aero (Human-Computer Interaction in Aerospace) conference series[16] in cooperation with ACM-SIGCHI, the International Ergonomics Association and the Air and Space Academy (Program Chair, 1998-2016).

HCI-Aero conferences have become a major reference in the field of HCI in Aerospace (full papers are indexed in the ACM Digital Library).

[21] He extended this HCD research effort on safety-critical systems to nuclear power plant control and management with two of his Ph.D. students.

His research work is globally summarized in the discussion on cognitive engineering he had with Jean Pinet, a former Experimental Test Pilot of Concorde,[22] and his dedication to automation, aerospace and education.