Guyana has participated in the South American Cricket Championship for some editions, but were represented by an overage "masters" team.

[3] Prominent cricketers who have played for Guyana include Devendra Bishoo, Basil Butcher, Shivnarine Chanderpaul, Colin Croft, Roy Fredericks, Lance Gibbs, Roger Harper, Carl Hooper, Leon Johnson, Alvin Kallicharran, Rohan Kanhai, Clive Lloyd, Veerasammy Permaul and Ramnaresh Sarwan.

From 1971 until the mid-1980s two Guyanese regional sides competed in an annual first class match for the Jones Cup, later renamed the Guystac Trophy.

In List A cricket, Guyana reached the final of the domestic competition four times in the early 2000s, but the last victory was in 2005–06.

In June 2018, Guyana was named the Best First-Class Team of the Year at the annual Cricket West Indies' Awards.