Guyandotte is a historic neighborhood in the city of Huntington, West Virginia, that previously existed as a separate town before annexation was completed by the latter.
The neighborhood is home to many historic properties, and was first settled by natives of France at the end of the eighteenth century.
A graveyard containing 18th-century French and Colonial-era settlers with surnames such as LeTulle, Holderby, and Buffington, continues to exist in the neighborhood.
The Confederate Army general Albert Gallatin Jenkins' plantation home, Green Bottom, is located in nearby Lesage.
On April 20, 1861, a group of men gathered outside the Planter's Hotel where a "secessionist" flag was raised by Elijah Ricketts and John W. Ong.
The next morning, the Confederates withdrew from Guyandotte and a detachment of the 5th West Virginia Infantry (Union) arrived.
The infantry burned a large portion of the town in response to the townspeople aiding the Confederates in their raid the day before.