It is notable chiefly for the Chapel of Ease, a rare example of church architecture of the Interregnum (1649–1660), and as a key crossing point of the River Nene.

[3] According to folklore, recorded in the early nineteenth century, Guyhirn was the site of "a severe engagement between a Saxon King and the abbot of Ely... the legend informs us that 5000 men were brought into the field... it arose from disputes respecting the boundaries of property.

[7] On the opposite bank of the River Nene is Ring's End where Bishop Morton erected a tower house to oversee his new drain.

[9] As a consequence, in the 17th and 18th century Calvinist Huguenot families, including the Culys, Snushells, Delahoi and the Tegerdines, settled in Guyhirn to drain outlying levels.

Until its demolition in 1990 for the widening of the A141 for the building of the new road bridge, the Ferry Boat Inn stood on the South Brink, the river's southern bank.

The railway bridge incorporated a footbridge, which allowed free passage between Guyhirn and Ring's End for pedestrians.

[12] The first road bridge across the Nene at Guyhirn was officially opened by Sir W. H. Clarke, Chairman of the Isle of Ely County Council, on 22 April 1925.

It was the result of a decades long campaign led by local county councillors William Weston and Richard Payne.

The current road bridge carrying the A47 across the river, was officially opened on 10 October 1990 by Malcolm Moss, MP for North East Cambridgeshire.

In 1877 "quantities of fine chiselled stone" were unearthed during the construction of the extant church, suggesting that this stands on or close to the location of the earlier chapel.

In the 1950s, it still stood and was known as The Institute, and was "the nightly rendezvous of about 40 young men who play billiards, darts and snooker there, or go merely to chat and drink a mineral around the stove with their chums.

[25] It remains a "a small, family centered [sic] Church of England Primary School that is committed to promoting our Christian values.

"[26] In Charles Kingsley's novel Alton Locke, he refers to Guyhirn, as Guy Hall, and describes the bodies of "two Irish reapers... hanging in chains by Wisbeach River."