It was renamed Guymon a month later by postal officials to avoid confusion with the town of Stratford, Texas, which was further down the line.

[4] Guymon's growth was helped when most of the businesses moved there from the nearby town of Hardesty.

It also had three banks, three hotels, four doctors, a flour mill, a grain company, and several retail establishments.

Some old-time residents remember "Black Sunday", April 14, 1935, as the day of the worst dust storm in the area's history.

However, discovery of the nearby Hugoton-Panhandle gas field created many new jobs, and brought Guymon's population to 2,290 in 1940.

The racial makeup of the city as of 2020 was 58.1% Hispanic, 29.3% non-Hispanic White, 3.6% Black, 5.6% Asian, 4.7% of two or more races, and 0.1% Native American.

[9] Guymon has been cited as an example of how immigration can save rural communities, most of which in Oklahoma and many other states have been losing population for decades.

Local manufacturers produce agricultural tillage tools, pressure tanks, and formula feeds.

Hitch Ranch, which began opening cattle feedlots during the 1960s, is the city's second-largest employer.

The City of Guymon, the Panhandle Telephone Cooperative, and the hospital round out the list of top employers.

[4] The employment opportunities created by these industries, especially of the Seaboard company, has led to an influx of Hispanics and recent immigrants to the U.S. which accounts for the population growth of Guymon and the surrounding area while most of Oklahoma's small cities and rural communities are losing population.

[10] A movement to harness wind power for electricity generation began a large-scale boom in the Guymon area in 2011.

Guymon schools were closed for one year during the Great Depression because funds were insufficient to keep them operating.

[14] About 30% of residents lack a high school diploma; the city has the lowest educational level in the state.

Commercial air transport is available out of Liberal Mid-America Regional Airport in Kansas,[19] about 41 miles northeast of town.