[4] Khan uploaded his first video to Facebook in 2014; in June of that year, he first performed on stage, opening for Aamer Rahman at Birmingham Repertory Theatre.

His second time on stage was at a comedy evening at the Library of Birmingham BBC Asian Network organised for Comic Relief, with Citizen Khan.

[2] In June 2015, whilst performing as his character Mobeen, a Muslim living in Small Heath,[2] Khan made a video called "Pakisaurus", expressing mock outrage at the lead character in the film Jurassic World[9][10] shouting the line "the Pachys are out of containment" (an abbreviation of Pachycephalosaurus),[9][11] observing it to be a homophone of Paki, a racial slur for people of South Asian descent.

In July 2015, Khan gave up his job as a school teacher to pursue a career in comedy after his YouTube clips went viral.

[34] In March 2022, Khan appeared in the HBO Max comedy pirate series Our Flag Means Death, where he played Ivan, a member of Blackbeard's crew.

In March 2024, Khan appeared in the Netflix show The Gentlemen, where he played Chucky "The Cobra" Kubra, an experienced money launderer.

In June 2019, Khan appeared in an advert for Walkers crisps alongside the Spice Girls, playing Dev, the group's biggest fan.

[36] In February 2020, Uber Eats launched a UK-wide brand campaign starring Khan as a charismatic courier spreading positivity.

In 2024, Khan played the voice of Santa Claus's sidekick reindeer Dasher in the Netflix and Locksmith Animation film That Christmas.