Gwydyr House was built for Peter Burrell of Beckenham, Kent, in 1772 at an estimated cost of £6,000.
The Secretary of State for Wales, Peter Hain, unveiled a plaque in Gwydyr House in March 2007 to mark the bicentenary of the Slave Trade Act 1807.
Gwydyr House is the location of the fictional Department for Administrative Affairs in the BBC sitcom Yes Minister.
In the pilot episode "Open Government", protagonist and Minister for Administrative Affairs, Jim Hacker MP, can be clearly seen entering the oak doors opposite Dover House on Whitehall.
The minister's office features a large Palladian window which offers a view of the chimneys of a Georgian home.