From 1927 onward, he worked at Ganz Rt, where he helped to develop diesel engines, of which the first few pieces were made with single and double cylinders.
Jendrassik started working at Ganz and Company - Danubius Electricity, Machine, Waggon and Shipyard Ltd.
His first work included the strength calculation and preparation of the load tests for the main girders of a new type of wagon for the Dutch coastal local railways.
The Ganz Study Department came up with the idea that Diesel engines, which until then had only been used in heavy-duty factory work, should be further developed to make them mobile and much smaller, so that they could also be fit in vehicles and in industries requiring less power, such as transport.
This was later developed into two-, four- and six-cylinder versions, which were stable, suitable for rail and marine propulsion, and which featured a combustion chamber in the front.
He set up a private office in 1934, where he and his colleagues designed a six-cylinder V-type diesel engine for Hispano-Suiza.
His achievements were also recognized by the Hungarian Academy of Sciences, which elected him as a corresponding member on May 14, 1943; however, due to the war, he could not hold his inaugural speech.
Later on, Jendrassik worked on gas turbines and in order to speed up research, he established the Invention Development and Marketing Co. Ltd. in 1936.
The next year he successfully ran a small experimental gas turbine engine of 100 hp.
Before the nationalization of large companies, the communist party of Mátyás Rákosi carried out a large-scale political campaign and disparaging propaganda activities against the rich industrialists and large entrepreneurs, and made the rich socially responsible for the poverty after the war.
Since 1949, Jendrassik has also been an external consultant of Power Jets (Research and Development) Ltd., with which he worked with until his death, on the development of a pressure exchanger; this is a promising type of heat engine in which the compression and expansion of a gaseous medium is effected by direct action of the gases involved without the employment of mechanical parts such ad pistons or blades[4] The number of his inventions on record only in Hungary is 77.