[4][5] Karki, who was born in Bhojpur in 1957 AD, entered party politics through the Nepal Students Union.

Karki, became the president of the Nepal Student's Union in 2039 BS succeeding former Deputy PM and NC Vice-president Bimalendra Nidhi in the post.

Karki, who was earlier in charge of the Ministry of Water Resources and Finance, is now in charge of the Ministry of Law, Justice and Parliamentary Affairs.

[5] Gyanendra Bahadur Karki won the 2017 Nepalese General Election from Sunsari-4.

In 2013 Constituent Assembly election, Karki didn't contest the election and was made MP from Proportional list of Nepali Congress.