Gypsum is a city in Saline County, Kansas, United States.

[3] For many millennia, the Great Plains of North America was inhabited by nomadic Native Americans.

In 1803, most of the land for modern day Kansas was acquired by the United States from France as part of the 828,000 square mile Louisiana Purchase for 2.83 cents per acre.

In 1860, Saline County was established within the Kansas Territory, which included the land for modern day Gypsum.

[7] According to the United States Census Bureau, the city has a total area of 0.36 square miles (0.93 km2), all land.

[9] The 2020 United States census counted 400 people, 173 households, and 101 families in Gypsum.

There were 188 housing units at an average density of 502.7 per square mile (194.1/km2).

33.5% of households consisted of individuals and 16.8% had someone living alone who was 65 years of age or older.

There were 187 housing units at an average density of 519.4 per square mile (200.5/km2).

27.2% of all households were made up of individuals, and 8.1% had someone living alone who was 65 years of age or older.

There were 179 housing units at an average density of 413.6 per square mile (159.7/km2).

25.3% of all households were made up of individuals, and 12.0% had someone living alone who was 65 years of age or older.

[23] The community is served by Southeast of Saline USD 306 public school district.