Quadrigyridae is the only family within Gyracanthocephala, an order of parasitic worms of class Eoacanthocephala.

This family contains two subfamilies, ten genera and about 92 species.

Species in Quadrigyridae are divided into two subfamilies: Pallisentinae Van Cleave, 1928 with five genera and Quadrigyrinae Van Cleave, 1920 with three.

[a] Golvan in 1959 divided the genus Acanthogyrus Thapar, 1927 into two subgenera: Acanthogyrus and Acanthosentis based on the number of proboscis hooks; there are 18 (3 circles of 6 hooks each) in Acanthosentis and 24 (3 circles of 8 hooks each) in Acanthogyrus.

[citation needed] Acanthogyrus (Acanthogyrus) Thapar, 1927 Acanthogyrus (Acanthosentis) Verma and Datta, 1929 Hexaspiron Dollfus and Golvan, 1956 contains two species: Palliolisentis Machado-Filho, 1960 contains three species: Pallisentis Van Cleave, 1928 is divided into three subgenera: Brevitritospinus, Demidueterospinus, and Pallisentis with 26 species:[2] Pallisentis (Brevitritospinus) Amin, Heckmann, Ha, Luc and Doanh, 2000 Pallisentis (Demidueterospinus) Amin, Heckmann, Ha, Luc and Doanh, 2000 Pallisentis (Pallisentis) Van Cleave, 1928 Pararaosentis Amin, Heckmann, Ha, Luc and Doanh, 2000 contains only one species: Raosentis Datta, 1947 contains five species: Triaspiron Smales, Aydogdu and Emre, 2012 contains only one species: Acanthodelta Diaz-Ungria and Gracia-Rodrigo, 1958 contains one species: Machadosentis Noronha, 1992 contains only one species: Quadrigyrus Van Cleave, 1920 contains 9 species: Quadrigyridae species parasitize fish.