He played in Major League Baseball (MLB) for the Chicago Cubs, Houston Astros, and Arizona Diamondbacks.

[3] With the addition of Aroldis Chapman in late July 2016, Rondon was moved to the setup role in the bullpen.

[7] During the shortened 2020 season, he made 23 relief appearances with the Diamondbacks, compiling a 7.65 ERA while striking out 23 batters in 20 innings; he recorded one win and no losses.

On February 2, 2021, Rondón signed a minor league contract with the Philadelphia Phillies organization and was invited to spring training.

[9] On April 3, 2021, Rondón signed a minor league contract with the Boston Red Sox organization.