[4] She became a deputy for Paris's 24th district to be part of the fifth legislature of the National Assembly on 26 July 1974, replacing her husband whose temporary mission as Minister of Foreign Affairs was extended past half a year.
[6] Missoffe won reelection to represent the 24th district of Paris in the seventh National Assembly legislature at the 1981 French legislative election held on 21 June 1981.
[1][4] She was made the Rally for the Republic's adviser for Paris in 1983 and was appointed chair of the Parliamentary Association for the Freedom of Education.
She made public speeches in support of bills to deal with unemployment and getting back into work and the formation of the French drug agency.
[4] Missoffe authored several articles in newspapers,[4] and she was appointed Officier de la Légion d'honneur.