de Fougerolles spent the first phase of her career in auteur cinema[7] appearing in such films as Jean-Pierre Mocky's Le Mari de Léon (1992), Patrice Chéreau's La Reine Margot (1994), Cédric Klapisch's Le Péril jeune (1994), Philippe Harel's The Story of a Boy Who Wanted to Be Kissed alongside Marion Cotillard, Mathieu Kassovitz's Assassin(s) (1997) or Baltasar Kormákur's The Sea (2002).

She played Madame de Pompadour twice, in Fanfan la Tulipe (2003) alongside Penélope Cruz[8][9] and Robin Davis' Jeanne Poisson (2006).

As of 2021, she has starred in more than 60 cinema, television and stage productions[10] and her book T'inquiète pas, maman, ça va aller (2021) about her daughter's autism[11][12] is published throughout the french-speaking world.

[13][14][15][16][17] De Fougerolles was born on 25 February 1973 in Vannes, Morbihan, France and spent years of her childhood in Guadeloupe.

[13][18] In 1999, de Fougerolles auditioned for Danny Boyle's The Beach to act alongside Leonardo DiCaprio but casting directors immediately told her that she was not mysterious enough as she arrived with blond hair in pigtails.