Hôpital Saint-Louis (French pronunciation: [opital sɛ̃ lwi]) is a hospital in Paris, France.

It is part of the Assistance publique - Hôpitaux de Paris hospital system, and it is located at 1 avenue Claude-Vellefaux, in the 10th arrondissement near the metro station Goncourt.

Hôpital Saint-Louis was built at the beginning of the 17th century on the orders of King Henry IV of France, who signed an edict founding the hospital on May 17, 1607.

It was initially intended to only serve as a temporary hospital during epidemic to quarantine afflicted Parisians who could be contagious.

On Friday, July 13, 1607, the king laid the first stone, and Antoine Le Mercier lead the construction efforts.