Hôpital Saint-Luc was a hospital in Montreal, Quebec, Canada, at the intersection of Saint Denis Street and René Lévesque Boulevard in the borough of Ville-Marie.

During the years of Great Depression following the 1929 stock market crash, agreements with the city provided a number of beds to be constantly available to the homeless patients collected by the police in addition to both domestic and foreign sailors from the Port of Montreal.

Hôpital Saint-Luc was notably the first hospital to offer 24-hour emergency services regardless of ethnic, linguistic or religious identity.

A chain of successive expansions took place thereafter, allowing Hôpital Saint-Luc to offer a total of 814 beds.

[3] In March 2005, construction of the CHUM megahospital was announced to be located on 1000 Saint-Denis on a site adjacent to Hôpital Saint-Luc.