Hôtel-Dieu Grace Healthcare is a 313-bed regional provider of post-acute care services in Windsor-Essex.

This includes all programs and services at the Prince Road campus such as complex care, palliative care, regional rehabilitation, cardiac wellness, bariatric services, specialized mental health and addictions, and children's mental health.

It was founded in 1888 by Dean James Theodore Wagner, pastor of St. Alphonsus Parish, and five sisters from the Religious Hospitallers of St. Joseph (RHSJ), who came from Hôtel-Dieu de Montréal on September 14, 1888.

Wagner had become concerned for the black people who had migrated from the southern United States to his parish, particularly the children in the community.

She was so moved that she sent Wagner $2.50 (equivalent to $90 in 2023) and wrote that if he were considering building a hospital in Windsor, her order would be happy to help.

Over the years Hôtel-Dieu of St. Joseph Hospital was renovated and expanded several times, adding more beds as the need arose.

After a fire destroyed a large portion of the hospital on June 6, 1960, approval was obtained to build a new five-story high, air-conditioned wing, which was officially opened in September 1966.