First erected in medieval times, the building originally served as the "Confrérie des frères pontifes" (est.

As Lyon was a city known for its trade and seasonal fairs, many of the early patients were weary travelers of foreign descent.

In fact, at its greatest point, the hospital extended from its present position beyond Place Bellecour to engulf the area now occupied by the central post office.

'Hôtel-Dieu' houses the "Musée des Hospices Civils" a permanent exhibit tracing the history and practice of medicine from the Middle Ages to modern time and includes a fine collection of apothecary vases amongst other objects.

In May 2015, it was announced that the building, which ceased to function as a hospital in 2010, would be converted into a high-end shopping and dining center.