The Hôtel-Dieu de Montréal (French pronunciation: [otɛl djø də mɔ̃ʁeal]; founded in 1645) was the first hospital established in Montreal, Quebec, Canada.

Its emergency room and function as an active hospital ended in 2017, and as of 2020 serves as a COVID-19 test site during the COVID-19 pandemic in Montreal.

[3] In addition to returning to France to seek financial support for the hospital, in 1657 Mance recruited three sisters of the Religious Hospitallers of St. Joseph (Religieuses hospitalières de Saint-Joseph) order of nuns to serve with her as staff.

With the completion of the CHUM megahospital campus adjacent to Hôpital Saint-Luc in 2017, the Hôtel-Dieu's patients were moved to the new facility as of November 5, 2017.

The Hôtel-Dieu was initially slated for closure, but ultimately remained open as a large-scale urgent care clinic until 2020.