[1] After Klinglin's disgrace and imprisonment in 1752, the hôtel became the seat of the royal Intendancy of Alsace, which it remained until the French Revolution.

Between 1789 and 1799, it was used as the seat of the Directoire du district and since 1800, it has served as the residency of the prefect of Bas-Rhin, with two intervals: between 1871 and 1918, it housed the Statthalter (governor) of Alsace-Lorraine and between 1940 and 1944, the Gauleiter.

During the Siege of Strasbourg in 1870, the hôtel was heavily damaged by Prussian artillery: the exterior walls withstood but the roof collapsed and almost all the interiors were destroyed.

It was rapidly rebuilt and refurnished using as much original material as possible; only the shape of the roof was modified and a balcony added.

The architect responsible for the reconstruction was Jean Geoffroy Conrath [fr], who also faithfully rebuilt the opera house nearby.