Nevers' secretary, Blaise de Vigenère, a distinguished antiquarian and art historian, wrote that the house had a vault, built by Italian workmen, which was more grand than the one at the Baths of Caracalla.

[4] The Hôtel de Nevers was a prominent early example in Paris of the brick-and-stone style developed in the Île-de-France in the middle of the 16th century.

[6] Although there is no documentation identifying the architect with certainty, the architectural historian David Thomson suggested Pierre Lescot or more likely Baptiste Androuet du Cerceau.

[12] The Hôtel de Nevers was purchased in 1646 by Henri de Guénégaud, who in 1643, during the regency of Anne of Austria under her first minister, Cardinal Mazarin, had become Secretary of State of the Navy, as well as Secretary of State of several regions of France (including Paris), the Maison du Roi, and ecclesiastical affairs.

The entrance façade, with a striking, rusticated porte-cochère, which was engraved by Jean Marot, became a prominent landmark on the Left Bank.

The latter sold it along with adjacent property in 1749 to form the site of a proposed new Hôtel de Ville, a project that was later abandoned.