The Hôtel de Vendôme (French pronunciation: [otɛl də vɑ̃dom]) is a private mansion in the 6th arrondissement of Paris.

The plans were published by Augustin-Charles d'Aviler in 1710 in his Cours d'architecture[2] under the title "Hôtel scis rue d'Enfer in Paris, occupied by M. le duc de Chaulnes et Batie on the designs of Sr le Blond".

[3] Leased to the Duchess of Vendôme, the hotel was remodeled in 1715-1716 by the same architect, who modified the facade overlooking the garden and created a new avant-corps with the pediment of the old one.

In the middle of the 18th century, it was occupied, following a long lease, by the 5th Duke of Chaulnes, Michel Ferdinand d'Albert d'Ailly, who died there in 1769, and his wife.

Adjoining the Luxembourg Gardens, onto which its rear façade overlooks, it has been the headquarters of the Mines Paris – PSL since 1815.