Hōjō Takatoki (北条 高時, 9 January 1304 – 4 July 1333) was the last Tokusō and ruling Shikken (regent) of Japan's Kamakura shogunate; the rulers that followed were his puppets.

Takatoki became regent at the age of eight, and thus actual power was held for a time by Adachi Tokiaki of Adachi clan, his grandmother, and Nagasaki Takasuke of Nagasaki clan, a minister and retainer of Hōjō assigned to him by his father Sadatoki.

That same year, the shogunal government asked Emperor Go-Daigo to abdicate in favor of his successor, in order to continue the tradition of cloistered rule and the alternation of branches of the Imperial family within the line of succession; Go-Daigo chose to maintain rule, and the ensuing controversy would lead to the Nanboku-chō Wars in which agents of the two Imperial branch families would come to outright war.

[1] In 1331, as events began to come to a boil, Takatoki argued with his advisor Nagasaki over how to react to the Burei-kō plot, in which members of the Hino clan, loyal to Go-Daigo, conspired against the shogunate.

This was but one of many events leading up to the outbreak of war, and the conflicts within the shogunal administration, between Takatoki and others, meant slow reactions and inadequate handling of such situations.