Hōjō Ujitsuna (北条 氏綱, 1487 – August 10, 1541) was a Japanese samurai lord of the Sengoku period.

He continued his father's quest to gain control of Kantō (the region around present-day Tokyo).

When Uesugi Tomooki died in 1537, Ujitsuna took the opportunity to occupy Musashi province and seize Kawagoe Castle to secure his control of the Kantō.

[1] In 1538, Ujitsuna then went on to win the battle of Kōnodai,[3] securing Shimōsa Province for the Hōjō.

[2] Over the next several years before his death in 1541, Ujitsuna oversaw the rebuilding of Kamakura, making it a symbol of the growing power of the Hōjō, along with Odawara and Edo.