HMCS Skeena was a River-class destroyer that served in the Royal Canadian Navy (RCN) from 1931 to 1944.

She was built by John I. Thornycroft & Company at Woolston, Hampshire and commissioned into the RCN on 10 June 1931 at Portsmouth, England.

Skeena and her sister HMCS Saguenay were the first ships specifically built for the Royal Canadian Navy.

Skeena rescued 65 survivors of the British merchant ship Manipur, sunk by U-57 off Cape Wrath on 17 July 1940.

On 2 September 1940 she rescued 19 survivors of the British merchant ship Thornlea, sunk by U-46 in the North Atlantic.