HMS Amphion was a Royal Navy 32-gun fifth-rate frigate of the Amazon class built in Chatham in 1780 which blew up on 22 September 1796.

On 6 September 1781, a small squadron under the command of Amphion's captain, John Bazely, in conjunction with General Benedict Arnold, completely destroyed the town of New London, Connecticut, together with stores and shipping in the harbour.

On 3 January 1782 Amphion recaptured the British sloop Bonetta, which the French had captured at the capitulation of Yorktown on 19 October 1781.

Among the few survivors was her captain, Israel Pellew, who went on to command a ship at the Battle of Trafalgar and ended the Napoleonic Wars as a Rear-Admiral.

The gunner had been suspected of stealing gunpowder, and on the day of the disaster he was reported to have been drunk and probably as a result less careful than usual.