That year she captured a Spanish letter of marque, Nuestra Senora del Corvodorvya (alias Asturiana), on 25 November 1799.

In October 1805 the captaincy was given to William Hoste at Lisbon, and he sailed to Gibraltar and subsequently Algiers before operating off Cádiz and Sicily.

On 25 November, Thunderer detained the Ragusan ship Nemesis, which was sailing from Isle de France to Leghorn, Italy, with a cargo of spice, indigo dye, and other goods.

Amphion succeeded in destroying the vessel without severe loss and in November joined HMS Unite off Trieste in the Adriatic.

On 8 December HMS Horatio, under the command of Captain Lord George Stuart, and Amphion captured the island of Showen during the Dutch uprising.

The two British ships landed a small joint force of marines and seamen, who met no opposition as the French surrendered first.

[9][a] In early 1814 Amphion continued to attack French shore positions along the North Sea coast but with the end of the war returned to Britain.