HMS Anguilla (K500) was a Colony-class frigate of the United Kingdom in commission from 1943 to 1946 that served during World War II.

Intended for transfer to the United Kingdom, the ship was renamed Anguilla by the British on 10 June 1943 and launched on 14 July 1943, sponsored by Mrs. John S. MacDonald.

Transferred to the United Kingdom under Lend-Lease on 15 October 1943, the ship served in the Royal Navy as HMS Anguilla (K500) on patrol and escort duty until 1946.

On 29 April 1945, while escorting Convoy RA 66 outbound from the Soviet port of Murmansk, she joined the frigates HMS Loch Insh (K433) and HMS Cotton (K510) in sinking the German submarine U-286 in the Barents Sea north of Murmansk at 69°29′00″N 033°37′00″E / 69.48333°N 33.61667°E / 69.48333; 33.61667 (U=286 sunk).

[2] The following day, Anguilla was forced to sink with gunfire the British frigate HMS Goodall (K479), which U-286 had heavily damaged.