Under Captain John Knight, she was flagship at the indecisive action of 28 April 1781 off Martinique against the French fleet of Rear-Admiral Comte de Grasse, at which Barfleur lost five men killed.

She saw further action in the French Revolutionary and Napoleonic Wars, taking part in Richard Howe's victory at the Glorious First of June as the flagship of Rear-Admiral (W) George Bowyer, with Captain Cuthbert Collingwood in 1794.

In this battle she engaged the French Indomptable on 29 May and took a major part in the general action of 1 June, with a total loss of 9 killed and 25 wounded.

D. M'Cleod, she served as the flagship of Rear-Admiral Charles Tyler and was engaged in the blockade of Lisbon and the escort to Plymouth of the first division of the Russian squadron commanded by Vice-Admiral Dmitry Senyavin.

[2] After the conclusion of the Napoleonic wars, Barfleur spent some years in ordinary at Chatham, and was finally broken up there in January 1819.