[1] Conqueror was initially commanded by Thomas Matthew Charles Symonds and formed part of the Channel Squadron.

[2] She was later assigned to operate in the Mediterranean during the Crimean War, and later was based out of Malta, when Hastings Yelverton took command on 22 July 1859.

Yelverton was succeeded by William John Cavendish Clifford, and he by James Willcox in 1860, by which time Conqueror had returned to Plymouth.

[2] Edward Southwell Sotheby took over command and was despatched to carry troops supporting the French intervention in Mexico in late 1861.

While sailing through the Bahamas, Conqueror was wrecked on Rum Cay on 29 December 1861 due to a navigation error.