HMS Defence was a 74-gun third rate ship of the line of the Royal Navy, launched on 25 April 1815 at Chatham.

[1] HMS Defence was ordered on 23 March 1809 and laid down in May 1812 at Chatham Dockyard.

On 14 July 1857, Defence was badly damaged by an accidental fire at Woolwich, likely caused by spontaneous combustion in a recently delivered load of coal.

[2] The fire was extinguished by scuttling the ship, and the remains were subsequently broken up later that year.

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