HMS Holcombe was a Type III Hunt-class destroyer of the Royal Navy.

Once in the Mediterranean she was used on escort duties initially based at Gibraltar and subsequently at Algiers and then Malta.

Whilst escorting convoy KMS34 on 12 December 1943 her sister ship HMS Tynedale was torpedoed and sunk off Jijel, Algeria, by U-593 commanded by Kptlt.

The other escorts commenced to search for the submarine but U-593 managed to torpedo Holcombe during the hunt.

U-593 was sunk after being depth charged by two other escorts of KMS34, USS Wainwright and HMS Calpe, off Bougie, Algeria, in position 37°38′N 05°58′E / 37.633°N 5.967°E / 37.633; 5.967 on the following day.