La Malouine alone picking up 146 survivors from the SS Canonesa, Dalcairn, Empire Airman and the Frederick S. Fales.

On 7 January 1941, in company with another corvette, HMS Anemone, she assisted in the sinking of the Italian navy submarine Nani.

On 5 May, during an air raid on Belfast, Northern Ireland, La Malouine was damaged by a near miss and lost two of her crew killed.

La Malouine reached Archangel on 25 July, carrying 20 survivors from the Hartlebury who had been transferred from the cargo ship Empire Tide.

[2] After her return from the Soviet Union, in September 1942, La Malouine was back in the Mediterranean undertaking 4 more convoys before the end of the year.

1943 began with La Malouine escorting convoy KMS.6G during which, on 6 January, east of Algiers, the merchant vessel Benalbanach was lost along with approximately 400 lives.

Whilst escorting convoy OS.45, on 2 April, La Malouine picked up some of the 53 survivors from the torpedoed merchant vessel Katha, 515 kilometers (320 mi) west of Oporto.

On 16 April whilst en route to Port Said La Malouine assisted in the rescue of 72 crew from the liberty ship Meyer London which had been attacked and sunk with an aerial torpedo.

La Malouine returned to the UK and was decommissioned, eventually being scrapped at Gelliswick Bay, Milford Haven on 22 May 1947.