In October 1942, Opportune escorted Fleet Admiral Sir Andrew Cunningham on board the cruiser Scylla to Gibraltar in preparation for Operation Torch, the invasion of North Africa.

After ten days, she returned to Home Waters, escorting the battleship Duke of York and aircraft carrier Victorious to Scapa Flow.

During this period, she escorted convoy JW 53 through extremely tough weather and earned salvage money when she rescued the stricken merchantman John H. B. Latrobe from a German minefield.

In October 1943, Opportune was part of Operation Leader, escorting several Royal Navy ships and the US aircraft carrier USS Ranger in attacks on German positions in Bodø, Norway.

When, on 25 December, the German battleship Scharnhorst was reported to be hunting convoy JW 55B, Opportune was deployed to join the battle.

The German ship proved a tough opponent, and although she was outnumbered, outgunned and blinded by a direct hit to her radar, she managed to elude her pursuers for many hours.

In the new year, she was once again in Arctic convoy escort duty until March, when she was deployed in counter E-boat operations in preparation for the Normandy Landings, which would take place a few months later.

In April, when she was recalled for a boiler clean and minor re-fit, she was permanently assigned to Task Force 27 in the English Channel.

Many casualties were US Army personnel who were not properly trained and had difficulties with the life-jackets and other equipment, and drowned whilst awaiting rescue.

She didn't encounter a single hostile boat, although she did engage E-boats in July and August, while supporting operations in France.

Opportune remained in service after VJ Day and deployed at Portsmouth for submarine training and Local Flotilla duties until 1950.