[3] On 31 January 1828, Rattlesnake was part of a force of five British and two French ships that attacked the Greek island of Gramvousa, used as a base for piracy.

While most of the pirate's ships were destroyed by the Anglo-French force, the British frigate Cambrian ran aground after a collision with Isis and sank.

[7] On 26 May 1837, the Rattlesnake sailed to the Bay of Islands, New Zealand, in response to a request for help from James Busby, the British Resident, who felt threatened by fighting between Māori tribes.

[9] During the period 1841–42 she was involved in actions off Canton in the fleet commanded by Sir William Parker in the First Anglo-Chinese War (1839–42),[10] including the Battle of Chinhai on 10 October 1841[11] and the Yangtze river campaign in June–August 1842.

[13] Rattlesnake was the ship that rescued Barbara Crawford Thompson, who had been shipwrecked on Prince of Wales Island, North Queensland, aged 13 in November 1844 and spent the next five years living with the local Kaurareg people.