Towards the end of the year Regulus served off Cumberland Island, participating in the Battle of Fort Peter and capturing St. Simons, Georgia.

Roebuck was designed as such to provide the extra firepower a ship of two decks could bring to warfare but with a much lower draught and smaller profile.

From 1751 to 1776 only two ships of this type were built for the Royal Navy because it was felt that they were anachronistic, with the lower (and more heavily armed) deck of guns being so low as to be unusable in anything but the calmest of waters.

[5] Ships of the class built after 1782 received an updated armament, replacing small upper deck 9-pounder guns with more modern 12-pounders.

[7] Regulus joined the Channel Fleet, briefly serving in March as flagship to Rear-Admiral John Macbride who commanded a squadron of frigates in the Downs.

At this point Captain William Carthew replaced Oakes in command, sailing Regulus to return to Jamaica on 23 October.

[14][15] Having joined the Jamaica Station, on 6 April 1797 boats from Regulus and the 36-gun frigate HMS Magicienne raided Cape Roxo, Hispaniola.

[16] The harbour there was a haven for French privateers, and without taking any casualties the boats destroyed two gun batteries and captured or burned a group of thirteen ships.

Hearing an alarm bell sound and believing it meant that the French were attacking the nearby British-held Les Irois, the ships sailed into the bay.

The British loss was four killed and ten wounded, all from one of Magicienne's boats that had attempted to tow the privateer sloop away from the battery.

The lack of wind forced the crews to abandon two of their prizes, bringing the other three out of the bay at the cost of one man who was killed by grapeshot.

[7] Regulus was recommissioned by Commander Thomas Pressland in February; the ship then formed part of the transport fleet that sailed to the Mediterranean for the Egypt Campaign in October.

[28] Regulus continued to participate in Egyptian operations, with Pressland for several months commanding all of the Greek vessels in use by the fleet.

With the Napoleonic Wars having begun, the ship was refitted at Chatham Dockyard between December 1803, when Pressland left Regulus for a final time, and April 1804.

[26] Having been recommissioned under Captain Charles Boys, on 15 September Regulus was one of eight ships that were present at the capture of Flora de Lisboa off the coast of Le Havre.

[31] On 10 December 1805 Regulus formed part of the escort to the troop ships taking men to join the Hanover Expedition.

On 22 December the ships left the Downs for another attempt at Hanover, but continued to suffer in the poor weather conditions.

[7] Under Tailour Regulus conveyed troops to Lisbon in 1811 and in the Mediterranean Sea in 1813, recapturing the brig Fly on 11 September that year.

After several weeks spent acclimatising on the island, Regulus formed part of a convoy that took the marines to join the command of Rear-Admiral George Cockburn, employed in attacks in Chesapeake Bay.

[36] Working to support the British Army advance towards Washington, D.C., the next day Ramsay took his boats up the Patuxent to Upper Marlboro, Maryland.

[39] Cockburn left the Chesapeake with most of his force on 14 December, sailing for Amelia Island to complete a diversionary attack for the Gulf Campaign.

[44] Cockburn kept his force at Cumberland Island, planning an attack on Savannah, Georgia, before on 25 February news arrived that the war had ended.

[45] In March a party of Americans, including the politician Thomas Spalding, who was a resident of nearby Sapelo Island, came to Cockburn demanding the return of their slaves.

Spalding and Thomas M. Newell were allowed to address a crowd of several hundred ex-slaves stood on the deck of Regulus, pleading for their return.