The second HMS Talisman (N78), and the first to enter service under the name, was a T-class submarine of the Royal Navy.

Talisman had a relatively short but active career, spending most of her time in the Mediterranean.

One of her first actions was the capture of the French fishing vessel Le Clipper, which was then used to observe U-boat movements off the Gironde estuary before being brought into Falmouth, Cornwall.

She went on to sink two sailing vessels with its deck gun, the Vichy-French passenger ship Théophile Gautier and the Italian merchant Calitea, as well as destroying the grounded wreck of the German merchant Yalova.

She reported sighting a U-boat off Philippeville, Algeria on 15 September; a Gibraltar-based Sunderland of 202 Squadron was sent out and caught the Italian submarine, probably the Alabastro, on the surface and sank her.