HMS Tenacious was a T-class destroyer of the Royal Navy that saw service during the Second World War.

The ship served from 1943 to 1944 in the Mediterranean (where she shared in the sinking of U-boat U-453 and also several E-boats), and the Aegean and Greek islands.

HMS Tenacious was seconded to serve in East Indies Fleet, as part of the escort force of the 21st Aircraft Carrier Squadron in 1944–5, against the Japanese, then came under the command of the 3rd US Pacific fleet (Admiral Bull Halsey), and given a temporary pennant number D46 to enable identification by US naval forces.

On 23 January 1949 she arrived in Mersey for a refit and in November of that year was commissioned as a target ship for the 3rd Submarine Flotilla at Rothesay.

Tenacious was subsequently sold for scrapping in 1965 and arrived at Troon for breaking up on 29 June in that year.