HMS Thisbe was a 46-gun modified Leda-class fifth-rate frigate built for the Royal Navy during the 1820s.

[2] Thisbe, the second ship of her name to serve in the Royal Navy,[3] was ordered on 23 July 1817, laid down in August 1820 at Pembroke Dockyard, Wales, and launched on 9 September 1824.

[4] She was completed for ordinary at Plymouth Dockyard on 5 October 1824 and the ship was roofed over from the mainmast forward.

Thisbe was converted for service as a depot ship from 1850–63 and was loaned to the Missions to Seamen on 13 August of that year as a floating church;[1] Lord Bute paid for the necessary modifications.

Another redundant Leda-class frigate, HMS Hamadryad, was also moored in Cardiff and used as a hospital ship from 1866 to 1905.