HMS Usk was a British U class submarine, of the second group of that class, built by Vickers Armstrong, Barrow-in-Furness.

Usk spent most of her short career operating in the Mediterranean.

She sailed from Malta to patrol off the north west coast of Sicily on 19 April 1941.

Usk was later ordered to alter her position due to intense anti-submarine activity.

Subsequent events are unknown, but she most likely struck mines in the vicinity of Cape Bon some time after 25 April 1941.