HMS Walpole (D41) was a W-class destroyer of the Royal Navy.

The ship was built under the 1916–17 programme in the 10th Destroyer order.

Walpole was assigned to the 13th Destroyer Flotilla in the Grand Fleet after completion.

she was assigned to the 11th Destroyer Flotilla in September 1939 and served until almost the end of the Second World War.

She hit a mine on 6 January 1945 and was subsequently declared a constructive total loss and broken up at Thos.