She was built at Deptford Dockyard under the supervision of Master Shipwright John Hollond to a design by Surveyor of the Navy Joseph Allin.

[1] Anson had orders to convey Duchess Charlotte of Mecklenburg-Strelitz from Cuxhaven, Kiel to marry George III.

[2] During the return voyage the squadron was three times blown over to the Norwegian coast by westerly gales and took ten days to reach Harwich, which it did on 6 September 1761.

[3] The King embarked on Royal Charlotte in 1797 to visit the fleet at the Nore after the Battle of Camperdown, in order to honour Admiral Adam Duncan.

Contrary winds however prevented the ship from reaching the mouth of the Thames, and instead the King was blown back up river to Greenwich.